Greetings and salutations to our POPEn Ent. Village members and future members alike.
This is my first in a series of my many discussions with my great grandfather who I have come to find out was not only good to his wife, but was also one of the most brilliant, highly knowledgeable, multi-lingual, photographic memorizing, respected, influential men, that works has been used, stolen, borrowed, copied, uncredited, that has been #HIDden from us for over one hundred years.
Now the story about how come it took me so long to begin writing this is the fact that I had to OVERcome obstacles that our Ancestors knew by the time I accomplished its journey that I would be able to make this possible. It may sound different that what you're used to, but I assure you that it will all make sense like change for a dollar soon...
Now the only thing that I ask is that you bear with me because I'm not typing on my computer and I peck at the keys a little slower than some, but oh well!
Share if you care, and share if you don't...
Someone cares enough for the both of us.
And now....members and future members alike... We are going to allow our minds and hearts to be open and opened to achieve what was embed in our ORIGINAL DeeEnAye which is which fortunately still in our reach!
POPE Ben E. Ficial the First :
POPEfully all is well on this beautiful one? You were telling me of the most important subject to date, take us on a trip and let's put the definition and context of these true terms on the table so we can make adjustments where we're able.
Great Grandfather Dr. Ernest C. Dickson MD: I will take up today with you the subject of toxines. With the introduction of advanced methods in the bacteriological study of disease the observation was made that the effect of the development of bacteria in a given body could not be purely mechanical.
In certain diseases it was though that the lesions could be explained by the presence of the microorganism in the infected tissue. In such a disease as anthrax for instance, in which the microorganisms develop in great numbers in the blood, it was concluded that the ill effects might follow from the mere plugging of the capillaries and similarly in diseases belonging to the group of hemorrhagic septicaemias, in which there is very rapid development of the infecting microorganism in the blood it was again possible to think that the lesions could be explained on the basis of mechanical interference with the circulation.
We have in man no disease at all resembling hemorrhagic septicaemia, except possibly plague and even its resemblance is not very marked. Hemorrhagic septicaemia is a disease entirely of animals ; it affects various species and I think there is no animal which is immune to this disease. It is a disease which is peculiarly and rapidly fatal ; in 24 hours, for instance, a horse which has been infected by the organism of hemorrhagic septicaemia, will die and at autopsy one finds an enormous multiplication of the microorganisms in the blood. In man, however, we do not have similar conditions, with the possible exception, as I said, of plague, and in certain instances of streptococcus septicaemia which seems to have a certain amount of resemblance in that the microorganisms develop very rapidly in the blood stream. Even in cases of general infection in man in which the microorganisms are particularly abundant in the blood stream it seems impossible to explain the lesions simply by the mechanical presence of the microorganism in question. In the earliest days of bacteriology the suggestion was made by Koch that the lesions in man must be due, to a certain extent at least, to the presence in the body of substances produced by the development of the different disease producing bacteria.
The first attempt to isolate specific substances was made by Brieger and Cohn who obtained nitrogenous substances from putrefying animal fluids. These substances gave the chemical reactions of nitrogenous alkaloids, and it was supposed that they represented the active principles of the microorganisms. They were subsequently obtained from cultures of bacteria and Brieger and Cohn came to the conclusion that these substances, which they called ptomains were bacterial products and represented the specific principles which cased the lesions. Ptomains were thus isolated from putrefying animal fluids and from the cultures of microorganisms. Similar substances, known as leucomaines, had been found in the human body as the result of normal metabolism. This was the first attempt however, from a chemical standpoint, to find out anything about the poisonous products of bacteria.
The first application of this chemical work of Brieger and Cohn's was made by Brieger and Fraenkel, who in 1890 obtained an albuminous substance from cultures of the bacillus of tetanus. Tetanus is a disease produced by an anaerobic organism which infects the subcutaneous tissues. It is usually introduced with a certain amount of dirt and follows certain peculiar wounds - wounds in which the tissues are lacerated, and also in which a great deal of material is ground into the tissues. An ordinary cut or bruise does not produce tetanus. Certain varieties of wounds were especially know to result in tetanus as punctured wounds - gunshot wounds to a certain extent and railroad accidents where there is a great deal of laceration of tissue, were apt to be followed by tetanus.
The organism was discovered by Nicolaier who found that it had a perfectly characteristic morphology and could be cultivated, though with some difficulty, since it grows as an anaerobic bacillus and does not grow except on favorable media. It has a rather peculiar morphology a special point about the organism being that it has a spore in one end of the rod. Now in tetanus we have a disease in which the microorganism has a limited development. It grows only at the original site of infection and yet the effects produced by this organism are general. One of the characteristic effects is the tetanic spasm. Patients infected with the tetanus bacillus die in most frightful convulsions, the nerve centres especially being affected. Nevertheless, in an autopsy on a patient dead of tetanus, the only place in the body where you can find the tetanus bacillus is in a small circumscribed area at the point of the original infection. The microorganisms do not get into the blood and do not pass much beyond the limited area at the site of the injury.
In 1890 Brieger and Fraenkel obtained a substance from the tetanus cultures which the thought represented the poison of the tetanus bacillus. This substance was considered to be a toxic albumin or a proteid substance of unknown composition which was capable of producing the lesions found in men dead of tetanus infection. It has subsequently been shown that the toxic albumin which was obtained by Brieger and Fraenkel is not pure tetanus toxine; that it contains albuminous materials found in the cultures of the tetanus bacillus which are not the essential poisons, but that with these albuminous materials there is mixed a certain amount of what we now regard as a specific toxic substance. A similar observation was made by Faber in the same year. The method by which Brieger and Fraenkel obtained this toxic albumin was merely precipitating the cultures of the tetanus bacillus with alcohol. By this means they obtained a precipitate which contains what proteid there is in the cultures, together with the substance we now recognize to be the toxine.
In the following year, in 1891, Kitasato obtained the tetanus toxine by filtering off the bacteria from a culture of the tetanus bacillus. He found for instance, that one can kill with infinite small amounts of these filtrates mice, guinea pigs, rabbits, etc., and that these animals died in a way characteristic of the tetanus bacillus. He made the further observation that this substance was extremely susceptible to the action of heat. For instance, if it be heated to 65 degrees for five minutes it was destroyed ; if heated to 60 degrees for 20 minutes, and if heated to 55 degrees for one and a half hours it was likewise destroyed."
POPE Ben E. Ficial the First: I know that that is a great place to take a break knowing how we're changing the past beliefs of those once in charge of the chiefs.
Great Grandfather Dr. Ernest C. Dickson MD: I am ready when you are. Let's grab some refreshments and get ready to shock the party as we're just now getting started.
If I break you snooze button (keep it honest with yourself and your people, only you and our Ancestors will know)Donate (GROWnate) and or Join POPEn Ent. An opening is just POPEnNing up for you. No rapper, scholar, or a person with a subscription ever spoke or had smoke for addressing this seemingly low hanging fruit that has now not only admitted that they did it, they come out with a planned gimmick of a psychic ability of pre-making the scientific specific remedies and recommendations of combatting the effects of side dishes that no one thought it to be my business or opinion as to whether or not that I die with this. to only costing you sixth sense pre-ordered on this so I know that we need to have a huddle before we find out how much we are in trouble.
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