Was the Structural Basis for Enhanced Infectivity and Immune Evasion of SARS-CoV-2 Variants Created in the Same Lab?

References

1. 
   

   1. Kumar A, Prasoon P, Kumari C, Pareek V, Faiq MA, Narayan RK, et al. . SARS-CoV-2-Specific Virulence Factors in COVID-19. J Med Virol (2020) 93:1343–50. doi: 10.1002/jmv.26615 - DOI - PubMed

1. 
   

   1. Gobeil SM-C, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, et al. . Effect of Natural Mutations of SARS-CoV-2 on Spike Structure, Conformation, and Antigenicity. Science (80- ) (2021) 373(6555):eabi6226. doi: 10.1126/SCIENCE.ABI6226 - DOI - PubMed

1. 
   

   1. Cai Y, Zhang J, Xiao T, Lavine CL, Rawson S, Peng H, et al. . Structural Basis for Enhanced Infectivity and Immune Evasion of SARS-CoV-2 Variants. Science (80- ) (2021) 373:642–8. doi: 10.1126/SCIENCE.ABI9745 - DOI - PubMed

1. 
   

   1. McCallum M, Bassi J, De Marco A, Chen A, Walls AC, Di Iulio J, et al. . SARS-CoV-2 Immune Evasion by the B.1.427/B.1.429 Variant of Concern. Science (80- ) (2021) 373:648–54. doi: 10.1126/SCIENCE.ABI7994 - DOI - PubMed

1. 
   

   1. Gupta A, Madhavan MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, et al. . Extrapulmonary Manifestations of COVID-19. Nat Med (2020) 26:1017–32. doi: 10.1038/s41591-020-0968-3 - DOI - PubMed

1. 
   

   1. Siordia JA. Epidemiology and Clinical Features of COVID-19: A Review of Current Literature. J Clin Virol (2020) 127:104357. doi: 10.1016/j.jcv.2020.104357 - DOI - PMC - PubMed

1. 
   

   1. Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. . Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med (2020) 382:1708–20. doi: 10.1056/NEJMoa2002032 - DOI - PMC - PubMed

1. 
   

   1. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. . Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol (2020) 77:683–90. doi: 10.1001/jamaneurol.2020.1127 - DOI - PMC - PubMed

1. 
   

   1. Brown E, Gray R, Lo Monaco S, O’Donoghue B, Nelson B, Thompson A, et al. . The Potential Impact of COVID-19 on Psychosis: A Rapid Review of Contemporary Epidemic and Pandemic Research. Schizophr Res (2020) 222:79–87. doi: 10.1016/j.schres.2020.05.005 - DOI - PMC - PubMed

1. 
   

   1. Maharaj S, Bello Alvarez M, Mungul S, Hari K. Otologic Dysfunction in Patients With COVID-19: A Systematic Review. Laryngoscope Investig Otolaryngol (2020) 5:1192–6. doi: 10.1002/lio2.498 - DOI - PMC - PubMed

1. 
   

   1. Wu P, Duan F, Luo C, Liu Q, Qu X, Liang L, et al. . Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol (2020) 138:575–8. doi: 10.1001/jamaophthalmol.2020.1291 - DOI - PMC - PubMed

1. 
   

   1. Nishiga M, Wang DW, Han Y, Lewis DB, Wu JC. COVID-19 and Cardiovascular Disease: From Basic Mechanisms to Clinical Perspectives. Nat Rev Cardiol (2020) 17:543–58. doi: 10.1038/s41569-020-0413-9 - DOI - PMC - PubMed

1. 
   

   1. Kumar A, Faiq MA, Pareek V, Raza K, Narayan RK, Prasoon P, et al. . Relevance of SARS-CoV-2 Related Factors ACE2 and TMPRSS2 Expressions in Gastrointestinal Tissue With Pathogenesis of Digestive Symptoms, Diabetes-Associated Mortality, and Disease Recurrence in COVID-19 Patients. Med Hypotheses (2020) 144:110271. doi: 10.1016/j.mehy.2020.110271 - DOI - PMC - PubMed

1. 
   

   1. Gross O, Moerer O, Weber M, Huber TB, Scheithauer S. COVID-19-Associated Nephritis: Early Warning for Disease Severity and Complications? Lancet (2020) 395:e87–8. doi: 10.1016/S0140-6736(20)31041-2 - DOI - PMC - PubMed

1. 
   

   1. Neri I, Guglielmo A, Virdi A, Gaspari V, Starace M, Piraccini BM. The Red Half-Moon Nail Sign: A Novel Manifestation of Coronavirus Infection. J Eur Acad Dermatol Venereol (2020) 34:e663–5. doi: 10.1111/jdv.16747 - DOI - PMC - PubMed

1. 
   

   1. Marraha F, Al Faker I, Gallouj S. A Review of the Dermatological Manifestations of Coronavirus Disease 2019 (COVID-19). Dermatol Res Pract (2020) 127:104357. doi: 10.1155/2020/9360476 - DOI - PMC - PubMed

1. 
   

   1. Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, et al. . Attributes and Predictors of Long COVID. Nat Med (2021) 27:1–6. doi: 10.1038/s41591-021-01292-y - DOI - PMC - PubMed

1. 
   

   1. Mahase E. Covid-19: What do We Know About “Long Covid”? BMJ (2020) 370:m2815. doi: 10.1136/bmj.m2815 - DOI - PubMed

1. 
   

   1. Tenforde MW, Kim SS, Lindsell CJ, Billig Rose E, Shapiro NI, Files DC, et al. . Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients With COVID-19 in a Multistate Health Care Systems Network — United States, March–June 2020. MMWR Morb Mortal Wkly Rep (2020) 69:993–8. doi: 10.15585/mmwr.mm6930e1 - DOI - PMC - PubMed

1. 
   

   1. Kumar A, Prasoon P, Sekhawat PS, Pareek V, Faiq MA, Kumari C, et al. . Pathogenesis Guided Therapeutic Management of COVID-19: An Immunological Perspective. Int Rev Immunol (2020) 40:1–18. doi: 10.1080/08830185.2020.1840566 - DOI - PubMed

1. 
   

   1. Thierry AR. Host/genetic Factors Associated With COVID-19 Call for Precision Medicine. Precis Clin Med (2020) 3:228–34. doi: 10.1093/pcmedi/pbaa026 - DOI

1. 
   

   1. Zhang X, Tan Y, Ling Y, Lu G, Liu F, Yi Z, et al. . Viral and Host Factors Related to the Clinical Outcome of COVID-19. Nature (2020) 583:1–7. doi: 10.1038/s41586-020-2355-0 - DOI - PubMed

1. 
   

   1. Huang L, Yao Q, Gu X, Wang Q, Ren L, Wang Y, et al. . 1-Year Outcomes in Hospital Survivors With COVID-19: A Longitudinal Cohort Study. Lancet (2021) 398:747–58. doi: 10.1016/S0140-6736(21)01755-4 - DOI - PMC - PubMed

1. 
   

   1. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. . SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell (2020) 181:271–80.e8. doi: 10.1016/j.cell.2020.02.052 - DOI - PMC - PubMed

1. 
   

   1. Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E. The Spike Glycoprotein of the New Coronavirus 2019-Ncov Contains a Furin-Like Cleavage Site Absent in CoV of the Same Clade. Antiviral Res (2020) 176:104742. doi: 10.1016/j.antiviral.2020.104742 - DOI - PMC - PubMed

1. 
   

   1. Braun E, Sauter D. Furin-Mediated Protein Processing in Infectious Diseases and Cancer. Clin Transl Immunol (2019) 8(8):e1073. doi: 10.1002/CTI2.1073 - DOI - PMC - PubMed

1. 
   

   1. Xia S, Lan Q, Su S, Wang X, Xu W, Liu Z, et al. . The Role of Furin Cleavage Site in SARS-CoV-2 Spike Protein-Mediated Membrane Fusion in the Presence or Absence of Trypsin. Signal Transduct Target Ther (2020) 5:1–3. doi: 10.1038/s41392-020-0184-0 - DOI - PMC - PubMed

1. 
   

   1. Johnson BA, Xie X, Kalveram B, Lokugamage KG, Muruato A, Zou J, et al. . Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis. bioRxiv (2020) 2020.08.26.268854. doi: 10.1101/2020.08.26.268854 - DOI

1. 
   

   1. Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, et al. . Neuropilin-1 Facilitates SARS-CoV-2 Cell Entry and Infectivity. Science (80- ) (2020) 370:eabd2985. doi: 10.1126/science.abd2985 - DOI - PMC - PubMed

1. 
   

   1. Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C, et al. . Neuropilin-1 is a Host Factor for SARS-CoV-2 Infection. Science (80- ) (2020) 370:861–5. doi: 10.1126/science.abd3072 - DOI - PubMed

1. 
   

   1. Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, et al. . SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets Across Tissues. Cell (2020) 181:1016–35.e19. doi: 10.1016/j.cell.2020.04.035 - DOI - PMC - PubMed

1. 
   

   1. Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, et al. . SARS-CoV-2 Entry Factors Are Highly Expressed in Nasal Epithelial Cells Together With Innate Immune Genes. Nat Med (2020) 26:1–7. doi: 10.1038/s41591-020-0868-6 - DOI - PubMed

1. 
   

   1. Muus C, Luecken MD, Eraslan G, Waghray A, Heimberg G, Sikkema L, et al. . Integrated Analyses of Single-Cell Atlases Reveal Age, Gender, and Smoking Status Associations With Cell Type-Specific Expression of Mediators of SARS-CoV-2 Viral Entry and Highlights Inflammatory Programs in Putative Target Cells. bioRxiv (2020) 2020.04.19.049254. doi: 10.1101/2020.04.19.049254 - DOI

1. 
   

   1. Deshmukh V, Motwani R, Kumar A, Kumari C, Raza K. Histopathological Observations in COVID-19: A Systematic Review. J Clin Pathol (2020) 74:1–8. doi: 10.1136/jclinpath-2020-206995 - DOI - PubMed

1. 
   

   1. Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, et al. . A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell (2020) 27:125–136.e7. doi: 10.1016/j.stem.2020.06.015 - DOI - PMC - PubMed

1. 
   

   1. Bouhaddou M, Memon D, Swaney DL, Beltrao P, Krogan Correspondence NJ. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell (2020) 182:685–712. doi: 10.1016/j.cell.2020.06.034 - DOI - PMC - PubMed

1. 
   

   1. Klann K, Bojkova D, Tascher G, Ciesek S, Münch C, Cinatl J. Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication. Mol Cell (2020) 80:164–74. doi: 10.1016/j.molcel.2020.08.006 - DOI - PMC - PubMed

1. 
   

   1. Li S, Ma F, Yokota T, Garcia G, Palermo A, Wang Y, et al. . Metabolic Reprogramming and Epigenetic Changes of Vital Organs in SARS-CoV-2–Induced Systemic Toxicity. JCI Insight (2021) 6:e145027. doi: 10.1172/jci.insight.145027 - DOI - PMC - PubMed

1. 
   

   1. Thoms M, Buschauer R, Ameismeier M, Koepke L, Denk T, Hirschenberger M, et al. . Structural Basis for Translational Shutdown and Immune Evasion by the Nsp1 Protein of SARS-CoV-2. Science (2020) 369:1249–55. doi: 10.1126/science.abc8665 - DOI - PMC - PubMed

1. 
   

   1. Viswanathan T, Arya S, Chan S-H, Qi S, Dai N, Misra A, et al. . Structural Basis of RNA Cap Modification by SARS-CoV-2. Nat Commun (2020) 11:3718. doi: 10.1038/s41467-020-17496-8 - DOI - PMC - PubMed

1. 
   

   1. Anand P, Puranik A, Aravamudan M, Venkatakrishnan AJ, Soundararajan V. SARS-CoV-2 Strategically Mimics Proteolytic Activation of Human ENaC. Elife (2020) 9:e58603. doi: 10.7554/eLife.58603 - DOI - PMC - PubMed

1. 
   

   1. Wynne BM, Zou L, Linck V, Hoover RS, Ma HP, Eaton DC. Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines. Front Immunol (2017) 8:766. doi: 10.3389/fimmu.2017.00766 - DOI - PMC - PubMed

1. 
   

   1. Mutchler SM, Kleyman TR. New Insights Regarding Epithelial Na+ Channel Regulation and Its Role in the Kidney, Immune System and Vasculature. Curr Opin Nephrol Hypertens (2019) 28:113–9. doi: 10.1097/MNH.0000000000000479 - DOI - PMC - PubMed

1. 
   

   1. Chung MK, Karnik S, Saef J, Bergmann C, Barnard J, Lederman MM, et al. . SARS-CoV-2 and ACE2: The Biology and Clinical Data Settling the ARB and ACEI Controversy. EBioMedicine (2020) 58:102907. doi: 10.1016/j.ebiom.2020.102907 - DOI - PMC - PubMed

1. 
   

   1. Kumar A, Narayan RK, Kumari C, Faiq MA, Kulandhasamy M, Kant K, et al. . SARS-CoV-2 Cell Entry Receptor ACE2 Mediated Endothelial Dysfunction Leads to Vascular Thrombosis in COVID-19 Patients. Med Hypotheses (2020) 145:110320. doi: 10.1016/j.mehy.2020.110320 - DOI - PMC - PubMed

1. 
   

   1. Mason RJ. Thoughts on the Alveolar Phase of COVID-19. Am J Physiol Cell Mol Physiol (2020) 319:L115–20. doi: 10.1152/ajplung.00126.2020 - DOI - PMC - PubMed

1. 
   

   1. Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, et al. . Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med (2020) 383:120–8. doi: 10.1056/nejmoa2015432 - DOI - PMC - PubMed

1. 
   

   1. Sakamoto A, Kawakami R, Kawai K, Gianatti A, Pellegrini D, Kutys R, et al. . ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Serine Protease 2) Expression and Localization of SARS-CoV-2 Infection in the Human Heart. Arterioscler Thromb Vasc Biol (2020) 41:542–4. doi: 10.1161/ATVBAHA.120.315229 - DOI - PubMed

1. 
   

   1. Babapoor-Farrokhran S, Gill D, Walker J, Rasekhi RT, Bozorgnia B, Amanullah A. Myocardial Injury and COVID-19: Possible Mechanisms. Life Sci (2020) 253:117723. doi: 10.1016/j.lfs.2020.117723 - DOI - PMC - PubMed

1. 
   

   1. Lindner D, Fitzek A, Bräuninger H, Aleshcheva G, Edler C, Meissner K, et al. . Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases. JAMA Cardiol (2020) 5:1281–5. doi: 10.1001/jamacardio.2020.3551 - DOI - PMC - PubMed